Combating Opioid Addiction and Overdose: Advancing Science and Policy

The nation is facing an unprecedented epidemic of prescription and non-prescription opioid overdose. Solutions to this crisis will require collaborative multi-disciplinary teams of researchers from different schools and campuses.

Opioid Resources

Opioid Basics: Understanding the Epidemic Centers for Disease Control and Prevention Provides a brief introduction to the opioid epidemic in the United States. Links on the left-hand menu provide information on overdose prevention efforts, the rise of fentanyl, and opioid overdose data by year and state.
Painkillers Fuel Growth in Drug Addiction Harvard University Medical School Explains the science behind how addiction happens, who is at risk for opioid addiction, the sources of opioid painkillers, and treatment options for people living with opioid addiction.
Prescription Drugs: The Epidemic of Addiction in the U.S. Stanford University, Be-Well News Puts the opioid epidemic in historical context and provides a “big picture” look at how changes in medical prescribing practices, the pharmaceutical industry, and our understandings of pain have contributed to the opioid epidemic.
Opioid Overdose Reversal with Naloxone (Narcan, Evzio) National Institute on Drug Abuse Describes Naloxone, the medication that can rapidly reverse opioid overdose, and how it can be used, who may be authorized to administer it, and the opportunities and limitations of using Naloxone as a tool for combatting the opioid epidemic.
Opioid Overdoses: State Successes Centers for Disease Control and Prevention Highlights several successful state-level initiatives to combat the opioid crisis.
How Do Former Opioid Addicts Safely Get Pain Relief After Surgery? National Public Radio (NPR), Morning Edition Includes interviews with medical professionals and family of people living with opioid addiction, as well as a discussion of the struggle to navigate providing pain relief to patients who live with or who have overcome an addiction to opioids.
All Scientific Hands on Deck to End the Opioid Crisis  NIH Directors Blog Francis S. Collins, M.D., Ph.D., director of the National Institutes of Health (NIH) talks about the opioid crisis and the needs in research on the issue. 

Potential Funding Opportunities

The following spreadsheet is a working document of potential funding opportunities around prescription drug overdose and pain management topics, as identified by UNC Injury Prevention Research Center. Potential Funding Opportunities

Slides from Tamera Haegerich, PhD, National Center for Injury Prevention and Control, CDC

Slides from Wilson Compton, MD, MPE, National Institute on Drug Abuse

The Current Landscape of PDO/Pain Management Research at UNC

Please help us in mapping the current landscape of PDO/pain management research at UNC. The information collected in this form will be shared with the others working in similar topics and help us in finding opportunities across campus. Include any information that you wish to share, but don’t include information that you prefer to keep private. All items are optional.

PDO Research Form

Current Research Tracks

On Thursday, May 25th researchers from across UNC and the Research Triangle came together to discuss and examine the different ways to tackle the opioid crisis. Attendees from this event were divided into two tracks.

In track #1, investigators will work in interdisciplinary teams to develop pre-proposals in some of the following areas: the importance of data; community driven approaches to the problem; pre-clinical and clinical research, and the special connection of HIV and the crisis.

In track #2, the audience will learn about issues related to the opioid crisis, including ongoing efforts in North Carolina for prevention, advocacy, and treatment; about transitions from opioid addiction to other health problems; and the biological, clinical, etiological, social, and policy-related aspects of the problem.

See full agenda here.

Introduction to the Opioid Addiction and Overdose Crisis Presentations

Opioid Disorders and Treatment— Slides from Mark Edlund, PhD; Senior Research Public Health Analyst Behavioral and Urban Health, RTI International

The Downstream Effects: Transition to Other Health Problems and review of the Harm Reduction Coalition— Slides from Robert Childs, MPH; Executive Director, NC Harm Reduction Coalition

Overview of US and NC Drug Overdoses and Prevention Efforts and Surveillance Data Used to Monitor, Track and Evaluate the Opioid Epidemic— Slides from Scott Proescholdbell, MPH; Epidemiologist, Injury and Violence Prevention Branch, Chronic Disease & Injury Section Division of Public Health, NC DHHS

Speakers

Wilson Compton, MD, MPE Deputy Director, NIDA Office of the NIDA Director National Institute on Drug Abuse National Institutes of Health, Bethesda, MD
Scott Proescholdbell, MPH Epidemiologist, Injury and Violence Prevention Branch, Chronic Disease Injury Section, Division of Public Health, NC DHHS Scott.Proescholdbell@dhhs.gov
Brooke Chidgey, MD Assistant Professor, Department of Anesthesiology, Division of Pain Medicine, UNC School of Medicine  Brooke_Chidgey@med.unc.edu
Tamara Haegerich, PhD Deputy Associate Director for Science, Division of Unintentional Injury Prevention, National Center for Injury Prevention and Control, CDC Egd4@cdc.gov
Robert Childs, MPH Executive Director, NC Harm Reduction Coalition Robert.bb.childs@gmail.com
Brian Pence, PhD Associate Professor, Epidemiology Operations, Gillings School of Global Public Health  Bpence@unc.edu
Alice Ammerman, DrPH Director  UNC Center for Health Promotion and Disease Prevention & Professor of Nutrition, Gillings School of Global Public Health  Alice_Ammerman@unc.edu
Kimberly Powers, PhD  Assistant Professor Department of Epidemiology Gillings School of Global Public Health  powersk@email.unc.edu
Christopher Ringwalt, DrPH Program Lead for Prescription Drug Overdose, Injury Prevention Research Center and Senior Scientist, Adjunct Professor, Gillings School of Global Public Health  cringwalt@email.unc.edu
Sherri L. Green, PhD, LCSW, MSW  Research Fellow, Sheps Center for Health Services Research & Research Assistant Professor Department of Maternal & Child Health Gillings School of Global Public Health  sgreen@email.unc.edu
Mark Edlund, MD, PhD Senior Research Public Health Analyst, Behavioral and Urban Health, RTI International medlund@rti.org
Michelle Jonsson-Funk, PhD  Research Associate Professor Department of Epidemiology Gillings School of Global Public Health  mfunk@unc.edu
Jon Easter BSPharm Professor of the Practice, Practice Advancement, UNC Eshelman School of Pharmacy  jceaster@email.unc.edu

Planning Committee

Marisa Domino, PhD Professor, Health Policy and Management, Gillings School of Global Public Health  Domino@unc.edu
Shabbar Ranapurwala, PhD, MPH Research Assistant Professor, Epidemiology, Gillings School of Global Public Health sirana@email.unc.edu
Stephen W. Marshall, PhD* Director, Injury Prevention Research Center; Professor, Epidemiology, Gillings School of Global Public Health smarshall@unc.edu
Eva Elmore Bland, MA Public Communication Specialist, UNC Injury Prevention Research Center ebland@unc.edu
David B. Peden, MD, MS* Director, Team Science, NC Translational and Clinical Sciences (NC TraCS) Institute; Distinguished Professor, Microbiology and Immunology; Director, CEMALB, UNC School of Medicine David_Peden@med.unc.edu
Karen Demby, PhD Administrative Director for Team Science, NC Translational and Clinical Sciences (NC TraCS) Institute  Karen_Demby@med.unc.edu
Christin Daniels, MA Director of Research, Research and Innovation Solutions, Gillings School of Global Public Health  Christin_Daniels@unc.edu
Bob Duronio, PhD Associate Dean for Research, Office of Research, UNC School of Medicine; Professor, Biology Duronio@med.unc.edu

*Planning committee member and presenter